Hashish and hemp crops have over 400 distinct chemical compounds. Of these compounds, over 100 are cannabinoids. Cannabinoids are the therapeutic compounds primarily discovered on the buds of cannabis or hemp crops. Whereas tetrahydrocannabinol (THC) and cannabidiol ( CBD) have been essentially the most researched and commercially accessible cannabinoids, the way forward for the cannabis trade lies in its minor cannabinoids.
One of the vital essential minor cannabinoids discovered within the cannabis plant is cannabigerol (CBG). In mature crops, CBG ranges are nearly nonexistent. Restricted CBG analysis has proven that the cannabinoid has potent anti-microbial, anti-bacterial, anti-inflammatory, and lots extra well being advantages.
CBG is a non-intoxicating compound that’s believed to be essential in treating debilitating medical situations akin to irritation, most cancers, glaucoma, gastrointestinal points, reminiscence points, hypertension, and different debilitating situations. CBG is commonly known as a “stem cell cannabinoid” or a “mom cannabinoid” as a result of its precursor acidic compound, cannabigerolic acid (CBGA), is the constructing block for main cannabinoids like THC and CBD.
Historically, most cannabis crops have lower than one p.c CBG at harvest. Some breeders and hemp producers are using modern cultivation methods to provide increased ranges of CBG. Researchers imagine that cannabis crops have peak CBG ranges between six and eight weeks into their flowering cycle.
How CBG Works
In the course of the cannabis flowering cycle, plant enzymes known as synthases alter the cannabinoids within the plant. The CBDA synthase converts CBGA to CBDA. The THCA synthase converts CBGA to THCA.
Most cannabis strains are left to mature sufficient in order that the CBGA is synthesizes into cannabinoids which are extra in demand like THCA and CBDA. You’ll be hard-pressed to search out strains with high-CBG concentrations in most dispensaries. If a marijuana plant is harvested earlier, throughout peak ranges of CBGA, the CBGA could be decarboxylated into CBG.
Decarboxylation happens once you apply warmth to the acidic types of cannabinoids akin to THCA, CBDA, and CBGA. Throughout decarboxylation, these compounds lose one carbon atom and convert into the energetic THC, CBD, and CBG cannabinoids.
Medical Advantages of CBG
CBG isn’t as extensively researched as different cannabinoids. We do know that our physique has a community of endocannabinoid cell receptors that comprise the endocannabinoid system (ECS). The ECS has two principal cannabinoid receptors: CB1 and CB2. Modulation of those receptors restores stability in organic methods within the physique.
CBG has been proven to work together with each CB1 and CB2 receptors. CBG is believed to cut back the detrimental unwanted side effects of THC akin to paranoia. As a CB1 receptor agonist, CBG is believed to extend the endocannabinoid anandamide, which performs a significant function in sleep, temper, urge for food, and immune system perform. CBG additionally binds with CB2 receptors within the immune and gastrointestinal methods.
Whereas CBG isn’t as broadly analysis as different cannabinoids, some early analysis reveals that CBG has a number of medical functions. Extra analysis should be carried out earlier than we perceive how CBG interacts with our physique and different cannabinoids. For now, CBG has proven therapeutic potential in instances of glaucoma, irritation, bladder dysfunction, and different situations.
A 1990 examine carried out by the Division of Ophthalmology on the West Virginia College Well being Providers Middle in contrast the consequences of CBG and THC on intraocular strain in cats and rats. Researchers discovered “that cannabigerol and associated cannabinoids could have therapeutic potential for the therapy of glaucoma.”
A 2007 examine printed within the Journal of Dermatological Science examined the consequences of THC, CBD, CBN, and CBG on irritation brought on by psoriasis. The examine’s findings decided that every one cannabinoids, together with CBG, slowed the expansion of keratinocytes on the pores and skin’s outer layer. Psoriasis sufferers develop pores and skin cells at a speedy tempo, so slowing down cell progress could be useful.
In 2013, one other examine discovered that CBG had anti-inflammatory properties. Researchers investigated the impact of CBG in rats with induced colitis. CBG lowered colon irritation in rats. The findings counsel that extra analysis must be devoted to CBG therapy for signs of inflammatory bowel illness (IBD).
A 2008 examine printed within the Journal of Pure Merchandise discovered that CBG had antimicrobial and antibacterial traits. The examine concluded that CBG might be used within the therapy for methicillin-resistant Staphylococcus aureus (MRSA). MRSA is a kind of staph an infection that’s tougher to deal with than most strains of the bacterium.
In a 2015 examine printed in Neurotherapeutics, researchers studied the consequences of CBG in two completely different in vivo fashions of Huntington’s illness (HD). Surprisingly, researchers discovered that CBG was “extraordinarily energetic as a neuroprotectant,” in addition to “improved the degrees of antioxidant defenses.” Researchers concluded that CBG might be used alone or together with different cannabinoids to deal with neurodegenerative ailments like HD.
CBG has been proven to assist with a number of elements of conventional most cancers signs and coverings. For instance, a 2016 examine discovered that CBG may stimulate urge for food in chemotherapy sufferers. One other examine printed in the identical yr concluded that CBG and different non-psychoactive cannabinoids may inhibit tumor development and improve the efficacy of most cancers therapy.
A 2015 examine printed in Pure Product Communications studied the impact of CBD, CBG, CBDV, THCV, and CBC on an animal mannequin’s bladder contractility. Researchers found that CBG and THCV may scale back bladder contractions. CBD and CBDV additionally lowered bladder contractions, however not as successfully as CBG and THCV.
For now, there aren’t that many growers and retailers that supply CBG-forward cannabis merchandise, however many corporations are actively submitting patents for brand spanking new CBG-infused options. CBG stays a uncared for byproduct of a profitable harvest. Most cannabis and hemp growers aren’t harvesting their crops early when the demand is in THC and CBD-rich buds.
As extra analysis trickles in on the efficacy of CBG and different minor cannabinoids on medical situations, customers will use a variety of cannabinoids in various ratios. Though CBG is probably not the most well-liked cannabinoid round, research counsel that it might be much more useful in sure conditions than different main cannabinoids.