Hashish sativa, also referred to as marijuana or hemp, produces a non-psychoactive compound cannabidiol ( CBD). To research the defensive position of CBD, a feeding desire assay was carried out with tobacco hornworm Manduca sexta. The larvae clearly present feeding desire in the direction of the Hashish tissue containing low CBD over excessive CBD. Whereas the larva prevented the excessive CBD food regimen, we investigated detrimental results of CBD within the bugs’ food regimen. Contrasted to the efficiency on low CBD-infused synthetic food regimen (AD), larvae reared on the excessive CBD food regimen undergo considerably lowered progress and elevated mortality. Via testing completely different carriers, we discovered that the rise of EtOH within the food regimen is negatively correlated with insect improvement and behaviors. Notably, CBD therapy considerably improved ethanol-intoxicated larval survival price by 40% and likewise improved food regimen looking exercise, leading to elevated food regimen consumption. Electrophysiology outcomes revealed that the CBD-treated ganglia had delayed however a lot bigger response with electrical stimuli compared to the larvae reared on AD solely and EtOH-added food regimen. Our outcomes present CBDs’ defensive position towards pest bugs, which suggests its potential use as an insecticide. We additionally present proof that CBD alleviates alcohol-induced stress; consequently, bettering the efficiency and viability of M. sexta larvae.